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Results 1 - 4 of 4
EC Number Posttranslational Modification Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.7.11.7phosphoprotein 15 to 20 autophosphorylation sites in MHCK-B reside in the N-rich region of the kinase. Autophosphorylation of full-length MHCK-B has no effect on the kinase activity of the enzyme 721946
Display the word mapDisplay the reaction diagram Show all sequences 2.7.11.7phosphoprotein association with the actin cytoskeleton causes a drastic increase in the autophosphorylation activity of MHCK A, which is then activated 693303
Display the word mapDisplay the reaction diagram Show all sequences 2.7.11.7phosphoprotein autophosphorylation at Thr825 activates MHCK A at least 50fold, dephosphorylation of the residue reduces the activity. The phosphorylated Thr825 docks intramolecularly into the phosphate-pocket. Allosteric activation is predicted to involve a conformational change in Arg734, which bridges the bound phosphate to Asp762 in a key active site loop 722716
Display the word mapDisplay the reaction diagram Show all sequences 2.7.11.7phosphoprotein MHCK A performs autophosphorylation, facilitated by F-actin requiring the coiled coil domain of the enzyme 662394
Results 1 - 4 of 4