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EC Number Posttranslational Modification Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.212glycoprotein HAS activity can be modulated by post-translational modification, such as phosphorylation and N-glycosylation 704558
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.212more HAS2 can be O-GlcNAcylated on serine 221, which strongly increases its activity and its stability to half-life of over 5 h versus 17 min without O-GlcNAcylation 722782
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.212more HAS2 is ubiquitinated on Lys190, HAS2 is both mono- and polyubiquitinated 722678
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.212more the treatments of plasma membranes or microsomal membranes with phosphatases or N-glycosidase F reveals that also HAS activity in internal vesicles can be modulated 736724
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.212phosphoprotein AMP-activated protein kinase, AMPK, phosphorylates HAS2 at Thr110, which inhibits its enzymatic activity. Isoenzymes HAS1 and HAS3 are not modified by the kinase 722741
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.212phosphoprotein ERK-mediated phosphorylation 692996
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.212phosphoprotein ERK-mediated serine phosphorylation of all the three HAS isozymes increases their specific activity. AMP activated protein kinase (AMPK) is considered a sensor of the energy status of the cell and is activated by low ATP:AMP ratio, AMPK leads to the inhibition of hyaluronan secretion by HAS2 phosphorylation at residue Thr110 736724
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.212phosphoprotein HAS activity can be modulated by post-translational modification, such as phosphorylation and N-glycosylation 704558
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.212phosphoprotein human HAS3 expressed in COS-7 cells is serine-phosphorylated. This phosphorylation can be enhanced by a number of effectors, most significantly by a membrane-permeable analogue of cAMP. Under non-stimulating conditions, the FLAG–HAS3 is phosphorylated to a stoichiometry of approx. 0.11 in COS-7 cells and, following maximal stimulation with 8-(4-chlorophenylthio)-cAMP, phosphorylation is increased to approximately 0.32 mol of phosphate/mol of protein 671862
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.212ubiquitination the enzyme is regulated by post-translational modifications, including ubiquitination. The deubiquitinating enzymes USP4 and USP17 target hyaluronan synthase 2 and differentially affect its function 759874
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