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EC Number	Posttranslational Modification	Commentary	Reference
2.1.1.348	sumoylation	METTL3 is modified by SUMO1 mainly at lysine residues K177, K211, K212 and K215, which can be reduced by an SUMO1-specific protease SENP1. SUMOylation of METTL3 does not alter its stability, localization and interaction with METTL14 and WTAP, but significantly represses its m6A methytransferase activity resulting in the decrease of m6A levels in mRNAs	745930

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Release 2023.1 (January 2023)