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EC Number	Posttranslational Modification	Commentary	Reference
1.14.16.4	more	less than 1% bound carbohydrate	438668
1.14.16.4	phosphoprotein	phosphorylation of TPH2 at Ser19 by calmodulin-dependent protein kinase II activates the enzyme	688504
1.14.16.4	phosphoprotein	TPH1 is phosphorylated by cAMP-dependent protein kinase A	659761
1.14.16.4	phosphoprotein	TPH2 is phosphorylated by cAMP-dependent protein kinase A	659761
1.14.16.4	phosphoprotein	TPH2 is phosphorylated by protein kinase A at Ser19 and Ser104, and by Ca2+/calmodulin dependent protein kinase II at Ser19, phosphorylation at Ser19 activates TPH2 by about 30%, Ser19 is phosphorylated to a stoichiometry of up to 50% in HEK-293 cells expressing TPH2, overview, in vivo phosphorylation in transiently transfected HEK-293 cells occurs with Ser19 phosphorylation stoichiometry of maximally 0.5 mol of phosphate/mol of enzyme subunit in resting cells, which is increasable by cell activation with okadaic acid, overview	684993
1.14.16.4	phosphoprotein	tryptophan hydroxylase becomes phosphorylated at Ser58 in brain stem of 1-month-old SAMP6	684813

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Release 2023.1 (January 2023)