EC Number |
Posttranslational Modification |
Reference |
---|
3.4.21.B12 | glycoprotein |
3 potential N-linked glycosylation sites: N134, N169, and N214 of the nucleotide sequence |
-, 647333 |
3.4.21.B12 | proteolytic modification |
recombinant chimeric enzyme with exchange of the pro-piece of the zymogen for that of prostate-specific antigen PSA to create an activation site suceptible for trypsin-type proteases proteolytically activates itself |
647338 |
3.4.21.B12 | glycoprotein |
2 N-glycosylated forms of different MW: 34 kDa and 37 kDa |
647339 |
3.4.21.B12 | glycoprotein |
deglycosylation abolishes enzyme activity |
647339 |
3.4.21.B12 | proteolytic modification |
no activation of recombinant zymogen by native KLK4 enzyme in vitro |
647339 |
3.4.21.B12 | proteolytic modification |
recombinant zymogen can be activated in vitro by thermolysin and by recombinant pig enamelysin |
647339 |
3.4.21.B12 | glycoprotein |
one glycosylation site |
691153 |
3.4.21.B12 | proteolytic modification |
KLK4 is secreted as an inactive zymogen, pro-KLK4 |
693377 |
3.4.21.B12 | proteolytic modification |
the enzyme performs proteolytic autoactivation |
731763 |