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Results 1 - 8 of 8
EC Number
Posttranslational Modification
Commentary
Reference
glycoprotein
the enzyme bears five N-glycosylation consensus sites per monomer
proteolytic modification
factor XI is activated to factor XIa by site-specific cleavage of zymogen factor XI by thrombin, factor XIIa, or autoactivation
proteolytic modification
factor XI is activated to factor XIIa at 37°C, a conformational transition accompanies conversion of factor XI to factor XIa that conceals the Apple 3 domain zymogen factor XI platelet binding site and exposes the factor XIa platelet binding site within the catalytic domain possibly comprising residues Cys527-Cys542
proteolytic modification
FXI activation proceeds through an intermediate with one activated subunit, limited digestion by incubating with FXIIa or thrombin
proteolytic modification
the enzyme shows activation by autolysis involving residues of the autolysis loops, overview
proteolytic modification
the zymogen FXI is activated by proteolytic cleavage to FXIa
proteolytic modification
the zymogen is activated by proteolytic cleavage
side-chain modification
glycoprotein, 11% carbohydrate
Results 1 - 8 of 8