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Posttranslational Modification
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2.3.1.286
phosphoprotein
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739439
2.3.1.286
phosphoprotein
phosphorylation of Thr522 is an important allosteric mechanism to activate SIRT1 in response to stress. While non-phosphorylation of this residue leads to formation of less-active oligomers, phosphorylation helps to maintain the monomeric status of SIRT1, resulting in increased activity
730947
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