EC Number   |
Application |
Reference |
|---|
   6.2.1.59 | medicine |
a FadD26 mutant has impaired synthesis of phthiocerol dimycocerosates and is attenuated in BALB/c mice. The FadD26 mutant induces less pneumonia and larger delayed-type hypersensitivity reactions. It induces lower but progressive production of interferon-gamma, interleukin-4 and tumour necrosis factor-alpha. Used as a subcutaneous vaccine, the mutant induces a higher level of protection than does strain Bacille Calmette-Guérin (BCG). There is less tissue damage (pneumonia) and lower colony-forming units in the mice vaccinated with the FadD26 mutant compared to the findings in mice vaccinated with BCG |
-, 753308 |
| 6.2.1.59 | medicine |
a SigE/FadD26 double mutant is more attenuated and more efficacious than wild-type strain BCG BCG in a mouse model of infection, and equivalent to BCG in a Guinea pig model of infection |
753809 |
| 6.2.1.59 | medicine |
comparison of parental virulent clinical isolate MT103 with its mutant FadD26, lacking phthiocerol dimycocerosates. Upon airways infection both mycobacteria behave similarly regarding T cell stimulation kinetics. They differ in the magnitude of these responses, in the bacterial load within tissues, and to trigger in vivo cytotoxicity in lungs and regional lymph nodes |
-, 755397 |
