EC Number   |
Application |
Reference |
|---|
    5.4.2.11 | biofuel production |
proteome analysis as well as enzyme assays performed in cell-free extracts demonstrates that glycerol is degraded via glyceraldehyde-3-phosphate, which is further metabolized through the lower part of glycolysis leading to formation of mainly ethanol and hydrogen. Fermentation of glycerol to ethanol and hydrogen by this bacterium represents a remarkable option to add value to the biodiesel industries by utilization of surplus glycerol |
748573 |
| 5.4.2.11 | drug development |
as a key enzyme in glycolysis and energy metabolism, PGAM is a potential target for novel antibiotics |
-, 726607 |
| 5.4.2.11 | medicine |
analysis of enzyme mutations found in some patients |
660903 |
| 5.4.2.11 | medicine |
both in erythroblasts and reticulocytes, increase in enzyme activity and mRNA level after application of triiodothyronine or induction of hypoxia by 90% nitrogen/10% oxygen. Propylthiouracil produces a decrease in enzyme activity |
661851 |
| 5.4.2.11 | medicine |
mutation M230I identified in a patient with non-spherocytic anemia. Enzyme activity is reduced by 50%, with normal levels of enzyme protein. Mutation results in decrease of glycolytic metabolites, with the exception of hexose phosphates. In contrast, lactate levels are increased |
661847 |
| 5.4.2.11 | medicine |
mutation M230I is identified in a patient with hereditary sperocytosis and 50% deficiency of enzyme activity in red blood cells. Enzyme shows abnormal behaviour on ion-exchange chromatography and is more thermo-labile than wild-type |
661261 |
| 5.4.2.11 | medicine |
PGAM1 may have a pathological role of vascular invasion into cancerous tissue |
694050 |
| 5.4.2.11 | medicine |
PGAM1 plays an important role in hepatocarcinogenesis, is a potential diagnostic biomarker as well as an attractive therapeutic target for hepatocellular carcinoma |
705672 |
| 5.4.2.11 | medicine |
the anti-PGAM1 antibody is a marker of autoimmune hepatitis and a nonspecific marker of central nervous system autoimmune diseases |
705270 |
