EC Number   |
Application |
Reference |
|---|
    4.2.1.78 | synthesis |
development of an efficient, stereoselective, green synthesis of (S)-norcoclaurine, i.e. higenamine, using the recombinant (S)-norcoclaurine synthase enzyme, starting from the cheap tyrosine and dopamine substrates in a one-pot, two step process, overview. The optimized process affords enantiomerically pure (S)-norcoclaurine (93%) in a yield higher than 80% and allows good recovery of the enzyme for recycling, by a green Pictet-Spengler synthesis |
715141 |
| 4.2.1.78 | synthesis |
the enzyme can catalyse the Pictet-Spengler reaction between dopamine and unactivated ketones, thus facilitating the facile biocatalytic generation of 1,1'-disubstituted tetrahydroisoquinolines. Variants of the enzyme showing improved conversions are identified and used to synthesize novel chiral 1,10-disubstituted and spiro-tetrahydroisoquinolines |
748745 |
| 4.2.1.78 | synthesis |
the enzyme can serve as a tool to synthesize unnatural, optically active tetrahydroisoquinolines. The enzyme is a promising catalyst that functions to stereoselectively produce various 1-substituted-1,2,3,4-tetrahydroisoquinolines |
747310 |
| 4.2.1.78 | synthesis |
the enzyme has also shown great potential as a biocatalyst for the formation of chiral isoquinolines |
747130 |
| 4.2.1.78 | synthesis |
the enzyme is a highly suitable catalyst for the Pictet-Spengler reaction |
747372 |
| 4.2.1.78 | synthesis |
the enzyme is a highly suitable catalyst for the Pictet-Spengler reaction. The enzyme is successfully immobilized on various carriers whereby EziG3 proves to be the best suited for biotransformations |
747372 |
