   3.6.4.B1 | medicine |
in muscles of patients with idiopathic inflammatory myopathies, KIF4-positive inflammatory cells are found. In polymyositis and inclusion body myositis, KIF4-positive cells are mainly located around individual muscle fibers, whereas in dermamyositis, KIF4-positive cells are also near blood vessels. KIF4-positive cells are not specific to any immune lineage. In peripheral blood lymphocytes stimulated with mitogens, KIF4 expression is upregulated, and the protein is localized in the cytoplasm associated with lysosome-associated protein 1+ and perforin+ lysosomal vesicles |
688535 |
