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EC Number Application Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.81medicine ADAM 10, 12 and 17 show different expression pattern in basal cell carcinomas histologic subtypes, indicating their different role in the basal cell carcinoma pathogenesis. Overexpression of ADAM 10, 12 and 17 immunoreactivity in deep invasion area of BCC indicates that these three proteases may play an important role in the locally invasive and highly destructive growth behavior of basal cell carcinomas 699201
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.81medicine ADAM10 as target for Alzheimer’s disease therapy 708492
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.81medicine ADAM10 participates in the response to infection by Staphylococcus aureus 644073
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.81medicine ADAM10 plays a critical role in Alzheimer’s disease. Tetraspanin12 serves as a robust partner for ADAM10 and promotes ADAM10 maturation, thereby facilitating ADAM10-dependent proteolysis of amyloid precursor protein. This mode of regulating amyloid precursor protein cleavage is of relevance to Alzheimer’s disease therapy. Promotion of TSPAN12-ADAM10-dependent functions should be therapeutically beneficial in Alzheimer’s disease, whereas inhibition of TSPAN12-ADAM functions may be beneficial in cancer 708462
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.81medicine cleavage by ADAM10 of beta-amyloid precursor protein could abolish production of longer peptides and slow down or arrest Alzheimer disease 644071
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.81medicine cleavage by metalloproteinase ADAM10 of PrP cellular protein is constitutive and could inhibit the maintenance of the toxic core of the protein PrP scrapie in spongiform encephalopathies 639004
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.81medicine Kuzbanian is required for pericardial cell and lymph gland development -, 681747
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.81medicine patients with nasopharyngeal carcinoma with high expression of the enzyme have shorter overall survival rates 753146
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.81medicine pharmacotherapeutic target for the treatment of cerebral amyloidosis in Alzheimer disease 669464
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.81medicine potential therapeutic target for the treatment of allergic diseases 680772
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