EC Number |
Application |
Reference |
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3.4.24.7 | analysis |
detection of localized extracellular sites of protease activity by use of fluorescent biosensor rhodamine 6G-labeled KDP-6-aminohexanoic acid-GPLGIAGIG-6-aminohexanoic acid-PKGY. Protease activity is localized at the polarized leading edge of migrating tumor cells rather than further back on the cell body. The path of proteolytic cleavage by a migrating cell can be visualized in 2- and 3-dimensional matrices. Probe can be used to determine inhibitor concentrations needed to suppress cell-surface protease activity |
699964 |
3.4.24.7 | analysis |
generation of specific recombinant human monoclonal antibody SP1, which may serve as building block for the development of antibody-based therapy strategies in mouse models of pathology |
-, 708420 |
3.4.24.7 | diagnostics |
MMP-1 is an inflammation and senescent cell marker |
709025 |
3.4.24.7 | diagnostics |
MMP1 is a potential oral cancer marker in gingiva, but not in neck tissue |
707648 |
3.4.24.7 | drug development |
MMP-1 enzyme inhibitor astragaloside IV is a potential agent against skin photoaging |
754756 |
3.4.24.7 | medicine |
glycine-extended gastrin renders colon cancer cells more invasive by increasing MMP-I expression via the putative glycine-extended gastrin receptor and would thus be a good molecular target in a clinical setting |
668978 |
3.4.24.7 | medicine |
high level expression of MMP-14 and MMP-2 are observed in ovarian clear cell carcinoma relative to other histotypes |
698145 |
3.4.24.7 | medicine |
in leg ulcer tissue from patients with chronic venous insufficiency, matrix metalloproteinases MMP-1, MMP-2, MMP-3, MMP-8, MMP-9, MMP-12, and MMP-13 protein levels are elevated. Following compression therapy, reduction of MMP-1, MMP-2, and MMP-3 levels is associated with significantly higher rates of ulcer healing at 4 weeks |
701420 |
3.4.24.7 | medicine |
in ovariectomized rats, during the first 1-4 weeks there is a significant increase in collagen accumulation and an increase MT1-MMP expression. Although active-form matrix metalloproteinase MMP-2 and collagen progressively return to normal levels, the markedly increased collagen deposition appears again at 8 weeks and persists until 12 weeks, followed by induction of MMP-2 and MT1-MMP at 12 weeks |
695444 |
3.4.24.7 | medicine |
in tear samples of vernal keratoconjunctivitis patients, matrix metalloproteinase-1, matrix metalloproteinase-2, matrix metalloproteinase-3, matrix metalloproteinase-9 and matrix metalloproteinase-10 are highly present in all samples |
695434 |