EC Number   |
Application |
Reference |
|---|
   3.4.24.65 | analysis |
the enzyme can be utilized for pharmacological evaluation of anti-inflammatory mechanisms of action |
683432 |
| 3.4.24.65 | diagnostics |
MMP12 is a no effect level oral cancer marker in neck tissue and gingiva |
707648 |
| 3.4.24.65 | diagnostics |
overexpression of HME is strongly correlated with the reduced angiogenesis and vascular invasion of gastric carcinoma, and may serve as a useful predictive indicator in patients with this disease |
708303 |
| 3.4.24.65 | drug development |
the enzyme is a target for drug development |
684029 |
| 3.4.24.65 | drug development |
the enzyme is a target in treatment of degradative disease processes in the skin |
683848 |
| 3.4.24.65 | medicine |
abnormal expression of HME may contribute to destructive processes such as pulmonary empysema and vascular aneurysm formation |
651860 |
| 3.4.24.65 | medicine |
chronic cigarette smoke exposure leads to macrophage accumulation and restores adipose MMP12 activity, thereby suppressing adipose tissue mass and vascularity |
733068 |
| 3.4.24.65 | medicine |
expression of macrophage metalloelastase improves the overall antitumor efficacy of oncolytic adenovirus in subcutaneous HCT116 xenografts. In a liver metastatic colorectal cancer model, intra-tumoral treatment of primary tumors from HT29 cells with macrophage metalloelastase monotherapy or with oncolytic adenovirus inhibits tumor growth. Combination therapy shows no increased mortality in comparison with either monotherapy alone. In a metastatic animal model, macrophage metalloelastase, as a monotherapy or in combination with oncolytic virus, does not increase tumor invasiveness |
733603 |
| 3.4.24.65 | medicine |
expression of MME12 inversely correlates with the expression of basic fibroblast growth factor and tumor angiogenesis in a model of murine colon cancer |
733705 |
| 3.4.24.65 | medicine |
in human ejaculate, MMP-12 concentrations are significantly higher in leucocytospermic samples than in nonleucocytospermic ones. The MMP-12 levels between the normozoospermic samples, oligoasthenoteratozoospermic samples and azoospermic samples do not differ. MMP-12 levels correlate with the presence of peroxidase-positive leucocytes. No correlation with CD 14 positive monocytes/macrophages is detected |
733087 |
