EC Number   |
Application |
Reference |
|---|
   3.4.24.34 | biotechnology |
human MMP-8 is coupled to epoxy activated silica matrix in an immobilized enzyme reactor which is used for the online screening of known MMP-8 inhibitors in zonal chromatography and inhibition experiments |
717905 |
| 3.4.24.34 | diagnostics |
correlation of salivary levels of MMP-8 and periodontal parameters of chronic periodontitis establish MMP-8 as a noninvasive marker for the early diagnosis of chronic periodontitis |
753668 |
| 3.4.24.34 | medicine |
breast cancer cell lines MCF-7, SKBR-3, and MDA-MB-231 expressing wild-type MMP-8 reveal elevated levels of interleukins IL-6 and IL-8. This increase is mirrored at the mRNA level and is dependent on MMP-8 catalytic activity. Sustained expression of wild-type MMP-8 by breast cancer cells is non-permissive for long-term growth.In long-term culture of transfected MDA-MB-231 cells, expression of wild-type but not E198A mutant MMP-8 is lost, with IL-6 and IL-8 levels returning to base line |
734213 |
| 3.4.24.34 | medicine |
design of anticancer or other drugs which should be highly selective for their particular MMP targets |
652117 |
| 3.4.24.34 | medicine |
elevated MMP-8 in bronchoalveolar lavage fluid is a marker of acute lung inflammation, and perhaps a contributor to acute lung injury, but is not necessarily an indicator of a poor outcome |
668885 |
| 3.4.24.34 | medicine |
implicated in cancer, arthritis, joint destruction and Alzheimer's disease |
651041 |
| 3.4.24.34 | medicine |
MMP-8 is critical for dexamethasone therapy in alkali-burned corneas under dry eye conditions. The anti-inflammatory effects of Dex are mediated through increased MMP-8 expression |
-, 754245 |
