EC Number   |
Application |
Reference |
|---|
   3.4.24.17 | analysis |
generation of specific recombinant human monoclonal antibody SP3, which may serve as building block for the development of antibody-based therapy strategies in mouse models of pathology |
-, 708420 |
| 3.4.24.17 | analysis |
unspecific staining in tissue sections of both animal strains with commercial anti-MMP-3 antibody JM3523 and positive but enzyme unspecific staining with the anti-MMP-3 antibody MAB 548 in both MMP-3 wild-type and MMP-3-deficient mouse skin wounds |
-, 755661 |
| 3.4.24.17 | diagnostics |
the enzyme, together with gelolin, is a potential biomarker for Alzheimer's disease |
734785 |
| 3.4.24.17 | drug development |
human enzyme MMP-3, i.e. stromelysin-1, is an anti-cancer drug target |
752877 |
| 3.4.24.17 | medicine |
attractive target for pharmaceutical design, implicated in diseases such as arthritis and cancer |
649875 |
| 3.4.24.17 | medicine |
development of natural pharmacological inhibitors of enzyme: Proenzyme is proteolytically activated by plasmin. C18 unsaturated fatty acids are inhibitory, with elaidic acid totally abolishing the activation. Inhibitory effect result from binding of unsaturated fatty acids to kringle 5 |
667543 |
| 3.4.24.17 | medicine |
during gastric ulcer healing, enzyme expression as well as matrix metalloproteinase MMP-2 and MMP-13 are induced in stromal cells of the gastric mucosa bordering the ulcer. Enzyme mRNA is confined to the upper layers of the granulation tissue |
668382 |
| 3.4.24.17 | medicine |
enzyme may be involved in the pathogenesis of endometriosis. Endometrial expression of enzyme, matrix metalloproteinases MMP-2 and MMP-11 and tissue inhibitor metalloproteinases TIMP-1 and TIMP-2 are similar in women with endometriosis and in those with peritoneal endometriosis. Expression of enzyme and matrix metalloproteinases MMP-2 and MMP-11 is higher in colorectal endometriosis than in ovarian and peritoneal endometriosis |
670991 |
| 3.4.24.17 | medicine |
enzyme overexpression im lymphoma transfectants significantly improves their ability to migrate through the matrix. Animals injected with lymphoma cells expressing enzyme constitutively develop thymic lymphoma more rapidly than those injected with control cells. Local expression of enzyme promotes lymphoma progression |
667382 |
| 3.4.24.17 | medicine |
important target for inhibitor design and synthesis because of the widespread implications in arthritis, cancer, and cardiovascular disease |
649839 |
