EC Number   |
Application |
Reference |
|---|
   3.4.22.70 | analysis |
development of a reverse-phase HPLC assay to identify and characterize sortase reaction intermediates |
677526 |
| 3.4.22.70 | analysis |
semisynthetic active site mutant enzymes containing selenocysteine and homocysteine might represent useful tools for further biochemical investigations and engineering approaches of sortases A |
731485 |
| 3.4.22.70 | biotechnology |
the bacterial transpeptidase sortase A is a well-established tool in protein chemistry and catalyzes the chemoselective ligation of peptides and proteins |
731485 |
| 3.4.22.70 | drug development |
the enzyme is a bona fide drug target |
731314 |
| 3.4.22.70 | drug development |
the enzyme is is a promising target for therapies against Gram-positive bacteria, in general, and staphylococci, in particular |
731478 |
| 3.4.22.70 | medicine |
4-vinylsulfonyl 5-phenyl prolinates inhibit Staphylococcus aureus sortase SrtA irreversibly by modification of the enzyme Cys184 and could be used as hits for the development of antibacterials and antivirulence agents |
691247 |
| 3.4.22.70 | medicine |
Bacillus anthracis SrtA anchors surface proteins bearing LPXTG motif sorting signals to the cell wall envelope of vegetative bacilli, srtA gene of Bacillus anthracis is not required for the development of acute anthrax disease in A/J mice |
669101 |
| 3.4.22.70 | medicine |
in principle the purified SrtA protein can be used to screen for compounds that inhibit cell wall sorting, a strategy that may lead to new therapies for human infections caused by Gram-positive bacteria |
647378 |
| 3.4.22.70 | medicine |
potential of inhibitors for the treatment of Staphylococcus aureus infections: (Z)-3-(2,5-dimethoxyphenyl)-2-(4-methoxyphenyl) acrylonitrile, beta-sitosterol-3-O-glucopyranoside, berberine chloride and psammaplin A1 |
663737 |
| 3.4.22.70 | medicine |
SrtA activity is a prime target for inhibition of Staphylococcus aureus colonization |
664024 |
