EC Number   |
Application |
Reference |
|---|
   3.4.22.6 | medicine |
enzyme is used for a number of biomedical applications |
695547 |
| 3.4.22.6 | medicine |
is used for chemonucleolysis of damaged human intervertebral spinal discs |
-, 81568 |
| 3.4.22.6 | medicine |
significantly more nucleus can be removed from a disc using a bilateral rather than a unilateral approach. A unilateral approach using rongeurs alone leads to removal of only about one-third of the nucleus. Rongeurs, followed by chymopapain, lead to removal of significantly more nucleus than when rongeurs are used alone. The most effective method is a bilateral approach using rongeurs followed by chymopapain where about three-quarters of the nucleus can be removed. This approach can create sufficient space for the implant insertion. A brush, which can be inserted through a trocar, assists in the removal of strands of nucleus that are loosened by chymopapain. Experiments are carried out on sheep spines since they are increasingly being used as models for human spines |
678944 |
| 3.4.22.6 | medicine |
used for pain relief in treatment of herniated invertebral disc |
695547 |
| 3.4.22.6 | nutrition |
at low pH, enzyme undergoes conformational transition leading to instability and rapid degradation by pepsin. To be effective in gut after oral administration, enzyme needs to be protected against acid denaturation and degradation |
667431 |
