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Results 1 - 10 of 15 > >>
EC Number Application Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.B12analysis enzyme-specific sandwich-type immunoassay using a monoclonal antibody, detection limit is 0.02 microgram per liter, and less than 0.1% cross-reactivity with other human kallikreins 668285
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.B12diagnostics four-kallikrein panel is a prostate screening test. An important proportion number of men presenting for biopsy falls outside the diagnostic grey zone, having a positive digital rectal exam or prostate-specific antigen 10-25 ng/ml. The four kallikrein panel has good discrimination in these men, and use of the panel reduces biopsy rates in this group of men by over 20%. The use of the panel in men with positive digital rectal exam or prostate-specific antigen 10-25 is justified 754526
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.B12diagnostics the enzyme is a biomarker in triple-negative breast cancer 752888
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.B12medicine enzyme might be useful as diagnostic marker in ovarian cancer 647332
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.B12medicine expression of the various tissue kallikreins like KLK4 in the endometrium and conceptus during the estrous cycle and early pregnancy in the pig can serve in the activation of growth factors and tissue remodeling during the establishment of pregnancy 682813
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.B12medicine K4 is not only expressed in prostate cancer cells, but also osteoblasts, in bone metastases. Thus, K4 may have proteolytic roles as a potential mediator of cellular interactions between prostate cancer and bone cells. Complex interactions may occur between prostate cancer and bone cells in the metastatic environment. Co-culture models are a crucial tool in evaluating cellular interactions 689848
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.B12medicine kallikrein 4 quantification serves as an independent biomarker for the discrimination between the malignant and the benign nature of prostate tumors 718348
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.B12medicine KLK-4 proteinase is essential for the final crystallite growth of enamel but is not critical for crystallite orientation, prism formation or enamel thickness 686543
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.B12medicine KLK4 can serve as a potential therapeutic target in patients with oral cancer. Inhibition of KLK4 expression results in diminished invasive potential in OSCC cell lines 752500
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.B12medicine KLK4 initiates Ca2+ mobilization via PAR-1 and PAR-2 but not via PAR-4. KLK4 has greater efficacy for initiating Ca2+ signalling via PAR-2 than PAR-1. Signals induced by KLK4 via PARs may be important in prostate cancer 687699
Results 1 - 10 of 15 > >>