EC Number   |
Application |
Reference |
|---|
   3.4.21.118 | analysis |
binding assessment of ligands to kallikrein-8 using a residue-wise decomposition of the binding energy. Use of chemical energy-wise decomposition or CHEWD for residue-wise decomposition of binding energies |
754264 |
| 3.4.21.118 | biotechnology |
enzyme might contribute to the remodeling of extracellular components after decidualization |
647329 |
| 3.4.21.118 | medicine |
clinical value of 11 members of the tissue kallikrein family as potential biomarkers for lung cancer diagnosis are evaluated: Serum specimens from 51 patients with non-small cell lung cancer and from healthy volunteers are collected. Compared with sera from normal subjects, sera of patients with non-small cell lung cancer have lower levels of KLK5, KLK7, KLK8, KLK10, and KLK12, and higher levels of KLK11, KLK13, and KLK14. Expression of KLK11and KLK12 is positively correlated with stage. A multiparametric panel of kallikrein markers for lung cancer diagnosis is provided with relatively good accuracy |
697372 |
| 3.4.21.118 | medicine |
imiquimod-treated skin of wild-type mice shows characteristic neutrophil microabscess formation in the epidermis, which is markedly reduced in Klk8 knockout mice. Klk8 is crucial for microabscess formation in the upper epidermis, where Klk8 is significantly involved in IL-36 expression |
753510 |
| 3.4.21.118 | medicine |
in hepatitis B patients, both serum KLK8 protein and estimated glomerular filtration rate increase significantly after long-term telbivudine treatment. No direct correlation is found between KLK8 increase and estimated glomerular filtration rate change. Estimated glomerular filtration rate change is positively associated with post-treatment KLK8 levels following adjustment for body height |
753790 |
| 3.4.21.118 | medicine |
in psoriatic lesion, KLK8 modulates hyperproliferation and prevents excessive hyperkeratosis by shedding the corneocytes |
-, 680875 |
| 3.4.21.118 | medicine |
KLK8 overexpression suppresses tumor growth and cancer cell invasion in a mouse model in vivo. Early-stage non-small cell lung cancer patients with high KLK8 expression have a lower recurrence rate than patients with low KLK8 expression. KLK8 can be used as a prognostic marker in early-stage non-small cell lung cancer patients |
679020 |
| 3.4.21.118 | medicine |
occurrence of two synaptic capture mechanisms for a weakly stimulated synapse to acquire persistency (i.e., neuropsin dependent and independent). Neuropsin-dependent late associativity may serve in the acquisition of nonaversive memory (e.g., inquisitive behavior) |
681546 |
| 3.4.21.118 | medicine |
patients with ovarian cancer, women with enzyme-positive tumors most often have lower-grade tumors, no residual tumor after surgery, optimal debulking success, and significantly longer progression-free survival and overall survival. Use of enzyme as independent marker of favorable prognsis in ovarian cancer |
668282 |
| 3.4.21.118 | medicine |
TAGD14 may be a useful molecular target for therapy or a diagnostic tool as tumor marker due to its overexpression in ovarian carcinoma |
647324 |
