EC Number   |
Application |
Reference |
|---|
   3.4.21.108 | medicine |
amyloid beta, a pivotal factor implicated in the pathogenesis of Alzheimer´s disease interacts with HtrA2/Omi |
670400 |
| 3.4.21.108 | medicine |
critical role of HtrA2 in a cytokine-induced cell death response. Inhibition by a viral protein |
689289 |
| 3.4.21.108 | medicine |
heterozygous G399S mutation in Parkinson's disease patients, which is absent in healthy controls, a A141S polymorphism is associated with Parkinson's disease, both mutations result in defective activation of Omi/HtrA2 and mitochondrial dysfunction associated with altered mitochondrial morphology |
668876 |
| 3.4.21.108 | medicine |
HtrA2 is linked to cancer and neurodegeneration, like Alzheimers disease, Parkinsons disease, Huntingtons disease, and brain, kidney and myocardial ischemia, reperfusion |
697488 |
| 3.4.21.108 | medicine |
HtrA2 is linked to Parkinsons disease |
697176 |
| 3.4.21.108 | medicine |
HtrA2 is regulated by Parkinson's disease-associated kinase PINK1. HtrA2 interacts with PINK1 and that both are components of the same stress-sensing pathway |
689124 |
| 3.4.21.108 | medicine |
HtrA2 knockout mice display features characteristic of a Parkinson syndrome, deletion of HtrA2 results in increased susceptibility to cell death stimuli, Smac/DIABOLO can compensate for the removal of HtrA2 in terms of neutralizing inhibitor of apoptosis proteins |
670241 |
| 3.4.21.108 | medicine |
HtrA2 under several different stress conditions induces cleavage of vimentin in wild-type as well as SH-SY5Y cells transfected with amyloid precursor protein with the Alzheimer disease-associated Swedish mutation. After stress treatment, inhibition of HtrA2 protease activity by the specific inhibitor, Ucf-101, reduces the cleavage of vimentin in wild-type cells |
754775 |
| 3.4.21.108 | medicine |
HtrA2-mediated proteolysis of WT1 may directly contribute to the effect of cytotoxic drugs warrants |
717632 |
| 3.4.21.108 | medicine |
HtrA2/Omi is associated with the pathogenesis of amyotrophic lateral sclerosis |
710093 |
