EC Number   |
Application |
Reference |
|---|
   3.4.19.13 | diagnostics |
ultrasensitive detection of glutathione according to its hydrolysis by gamma-glutamyl transpeptidase and the as-prepared simple and robust LC-based sensing platform has potentials in the diagnosis of glutathione-related diseases, e.g. cancer, liver damage, and malignant neoplasms |
752483 |
| 3.4.19.13 | medicine |
lysate from a gamma-glutamyl transpeptidase Ggt mutant strain shows a decrease of the capacity to inhibit Jurkat T cell proliferation. Incubation of Jurkat T cells with recombinantly expressed Ggt results in an impaired proliferation, and cell death is involved. A similar but more pronounced inhibitory effect is also seen on primary murine CD4+ T cells, CD8+ T cells, and CD19+ B cells. Supplementation with glutamine restores normal proliferation of the cells, whereas supplementation with reduced glutathione strengthens the enzyme-mediated inhibition of proliferation. Ggt treatment abolishes secretion of IL-4 and IL-17 by CD4+ T cells, without affecting secretion of IFN-gamma. Helicobacter suis outer membrane vesicles are a possible delivery route of Ggt to lymphocytes residing in the deeper mucosal layers |
732754 |
| 3.4.19.13 | medicine |
pharmacokinetics of S-(2-(4-chlorophenoxy)-2-methylpropanoyl)glutathione, i.e. clofibryl-S-acyl-glutathione, in urine of rats. gamma-Glutamyltransferase-mediated degradation of S-(2-(4-chlorophenoxy)-2-methylpropanoyl)glutathione leads primarily to the formation and excretion of clofibryl-N-acyl-cysteine products rather than the S-acyl-N-acetylcysteine conjugate. Clofibryl-S-acyl-glutathione is degraded to clofibryl-N-acyl-cysteinylglycine, clofibril-N-acyl-cysteine and their respective S-methylated products. The mercapturic acid conjugate is found as a minor product |
722037 |
| 3.4.19.13 | medicine |
the metabolism of S-(5-hydroxy-2-pentyltetrahydrofuran-3-yl)glutathione in the V79 GGT cell line is associated with a considerable increase of cytotoxicity. The cytotoxic effect is dose- and time-dependent, with 100% cellular death at 200 mM S-(5-hydroxy-2-pentyltetrahydrofuran-3-yl)glutathione after 24 h incubation in V79 GGT cells |
721414 |
| 3.4.19.13 | medicine |
the relatively small increase of glutathione amount in the presence of oxidative and electrophilic agents such as hydrogen peroxide or N-ethylmaleimide compared to other thiol reactive agents is not due to increased gamma-glutamyltranspeptidase-mediated degradation of glutathione |
721699 |
| 3.4.19.13 | medicine |
treatment of rats with diclofenac results in accumulation of diclofenac-N-acyl-cysteinylglycine and diclofenac-N-acyl-cysteine in bile, albeit only about 1% of the administered dose of diclofenac within 6 h |
703189 |
| 3.4.19.13 | pharmacology |
the enzyme is involved in a number of physiological and pathological processes through glutathione metabolism and is an attractive pharmaceutical target |
-, 752957 |
