EC Number   |
Application |
Reference |
|---|
   3.4.17.12 | diagnostics |
CPM, a gene that encodes carboxypeptidase M, is consistently amplified in liposarcomas but not in different subtypes of lipoma or normal fat, CPM could be used as an alternative and novel diagnostic tool for these tumors |
709860 |
| 3.4.17.12 | diagnostics |
expression is positively correlated with overall survival and negatively correlated with recurrence, lymph node invasion, and N stage in colorectal cancer |
754960 |
| 3.4.17.12 | medicine |
CPM might be an important target for the development of new drugs to treat inflammatory diseases and cancer |
668124 |
| 3.4.17.12 | medicine |
expression is positively correlated with overall survival and negatively correlated with recurrence, lymph node invasion, and N stage in colorectal cancer |
754960 |
| 3.4.17.12 | medicine |
patients with chronic persistent atrial fibrillation have reduced amounts of CPM mRNA and protein in the atrial tissue |
697395 |
| 3.4.17.12 | medicine |
the present data could lead to improved IHC tests in lung adenocarcinomas when the prognostic value of EGFR expression needs to be evaluated for a target therapy especially when EGFR gene exhibited to mutations |
683693 |
| 3.4.17.12 | medicine |
the rs12812500 variant of the carboxypeptidase M gene may increase silicosis susceptibility by affecting the expression of carboxypeptidase M, which may contribute to silicosis susceptibility with biological plausibility |
754933 |
| 3.4.17.12 | medicine |
tumor cells of renal cell carcinoma subtypes lose carboxypeptidase M expression upon dedifferentiation. There is a correlation between low carboxypeptidase M expression and tumor cell type. Carboxypeptidase M staining is intense on phagocytotic tumor-associated macrophages, and enzyme is also detected in the tumor-associated vasculature. Coexistence of carboxypeptidase M and the epidermal growth factor receptor is detected in papillary renal cell carcinoma |
732261 |
