EC Number   |
Application |
Reference |
|---|
   3.4.11.22 | analysis |
two-photon fluorescent probe SNCL exhibits high sensitivity toward ERAP1, with about a 95-fold fluorescence enhancement at 550 nm. SNCL can be applied for monitoring ERAP1 in tumor tissue with an imaging depth of 50-120 microm |
752481 |
| 3.4.11.22 | medicine |
a haplotype in the ERAP1 and ERAP2 locus (rs27044[G] rs30187[T] rs2549782[T]) is significantly associated with ankylosing spondylitis. ERAP1 single nucleotide polymorphism rs30187[T] is associated with ankylosing spondylitis |
707156 |
| 3.4.11.22 | medicine |
exposure of human peripheral blood mononuclear cells to isoform ERAP1 polymorphic variant proteins as well as ERAP1 overexpression increases inflammatory cytokine and chemokine production, and enhances immune cell activation. ERAP1 is able to activate innate immunity via multiple pathways, including the NOD-like receptor NLRP3 inflammasome. These responses vary if autoimmune disease-associated variants of ERAP1 are examined in the assay systems. Blocking ERAP1 cellular internalization augments IL-1beta production |
732285 |
| 3.4.11.22 | medicine |
in both HeLa-B27 and C1R-B27 cells, the proportion of 9-mer HLA-B27-bound peptides is decreased by isoform ERAP1 silencing, whereas the percentages of longer peptides, 11-13 mer, are increased. Following ERAP1 silencing, C-terminally extended peptides are readily identified. These are better able to bind to HLAB27 than N-terminally extended peptides lacking an arginine at position 2. In both HeLa-B27 cells and mouse fibroblasts expressing HLA-B27, the absence of ERAP1 reduces peptide recognition by HLA-B27-restricted immunodominant viral HLAB27 epitope KK10-specific cytotoxic T-lymphocytes. Presence of an ankylosing spondylitis-protective variant of ERAP1, K528R, as compared to wild-type ERAP1, reduces the peptide recognition by KK10 cytotoxic T lymphocytes following transfection with extended KK10 minigenes |
731234 |
| 3.4.11.22 | medicine |
the ERAP1 gene shows borderline association with preeclampsia in Australian and Norwegian populations |
708650 |
| 3.4.11.22 | medicine |
the specific ERAP1 haplotype, rs27044/10050860/30187-CCT is strongly associated with increased risk of ankylosing spondylitis, while a second specific ERAP1 haplotype, rs30187/26618/26653-CTG, reduces the disease risk |
707315 |
| 3.4.11.22 | medicine |
two-photon fluorescent probe SNCL exhibits high sensitivity toward ERAP1, with about a 95-fold fluorescence enhancement at 550 nm. SNCL can be applied for monitoring ERAP1 in tumor tissue with an imaging depth of 50-120 microm |
752481 |
| 3.4.11.22 | nutrition |
the enzyme is useful to reduce bitterness of food products by hydrolysis of peptides with hydrophobic amino acids causing the bitter taste |
664347 |
