EC Number   |
Application |
Reference |
|---|
   3.2.2.21 | medicine |
MPG overexpression is paradoxically associated with increased suspectibility to DNA damage, up-regulation of this gene may suggest a functional role in breast carcinogenesis, animal models using transgenic mice overexpressing the enzyme are being developed to determine the in vivo role of MPG in breast carcinogenesis |
646879 |
| 3.2.2.21 | medicine |
overexpression of MPG can result in increased kill of tumor cells using lower doses of harmful alkylating agents such as temozolomide and cross-linking agents such as cisplatin, use of lower doses of chemotherapeutic agents, which will decrease the emergence of drug-resistant tumor cells and decrease the need fro stem-cell support, leading to an increased patient response and a better quality of life for the patient |
646893 |
| 3.2.2.21 | medicine |
recombinant expression of enzyme and targeting to mitochondria or nucleus of primary astrocytes. Increasing enzyme activity significantly increases base excision repair kinetics in both the mitochondria and nuclei. Increased nuclear enzyme activity results in cell death in astrocyte cultures treated with methylnitrososurea |
680028 |
| 3.2.2.21 | medicine |
sulfur mustard, or mustard gas, bis-(2-chloroethyl)sulfide is carcinogenic to humans, acutely toxic to the skin, repiratory tract and eyes and causes a delayed bone marrow depression, knowledge of the DNA damage caused by this agent and the cellular defenses against this damage are of fundamental importance |
646876 |
