EC Number   |
Application |
Reference |
|---|
   3.2.1.18 | analysis |
ensemble-based virtual screening and relaxed complex scheme approach for structure-based drug discovery |
-, 699433 |
| 3.2.1.18 | analysis |
neuraminidase assay based on PNA hemagglutanation is highly sensitive, reproducible and can be used as a tool to detect sialidase activity in anaerobic bacteria, particularly, in species of the bacteroides fragilis group |
677512 |
| 3.2.1.18 | analysis |
subcloning of carbohydrate-binding module CBM40 of sialidase, showing high affinity for sialic acid and specificity to alpha(2,3), alpha(2,6), and alpha(2,8)-linked sialosides. Creation of polypeptides containing up to four CBM40 modules in tandem show increased affinities compared with the single module molecule. Variation in linker length has little effect on affinity |
698986 |
| 3.2.1.18 | analysis |
virtual screening method for inhibitors based on consensus scoring and ligand efficiency indices, which allows the combination of pharmacodynamic and pharmacokinetic properties into unique measures |
699143 |
| 3.2.1.18 | diagnostics |
a rapid separation of human liver and bone alkaline phosphatase is possible after treatment with the enzyme |
655515 |
| 3.2.1.18 | medicine |
bacterial neuraminidases functions as the predominant neuraminidase when influenza virus neuraminidase is inhibited to promote the spread of infection and to inactivate the neutralization activity of saliva. Neuraminidase from bacterial flora in patients may reduce the efficacy of neuraminidase inhibitor drugs during influenza virus infection |
-, 730707 |
| 3.2.1.18 | medicine |
construction of highly infectious laryngotracheitis virus expressing H5 hemagglutinin and/or N1 neuraminidase and use in ocular immunization of chickens. Animals immunized with laryngotracheitis virus expressing neuraminidase N1 died after subsequent H5N1 avian influenzy virus challenge, although survival times were prolonged compared to non-vaccinated controls. In contrast, all chickens vaccinated with either laryngotracheitis virus expressing hemagglutinin H5 alone, or hemagglutinin H5 and neuramindase N1 simultaneously, survived without showing any clinical signs |
-, 701369 |
| 3.2.1.18 | medicine |
in fibroblasts from patients with sialidosis, oversialylated lysosomal membrane protein Lamp-1 enhances lysosomal exocytosis. Silencing of Lamp-1 reverts this phenotype by interfering with the docking of lysosomes at the plasma membrane |
697537 |
| 3.2.1.18 | medicine |
in macrophages from isoform Neu1 deficient mice, a model for sialidosis, oversialylated lysosomal membrane protein Lamp-1 enhances lysosomal exocytosis. Silencing of Lamp-1 reverts this phenotype by interfering with the docking of lysosomes at the plasma membrane. In Neu1-/- mice the excessive exocytosis of serine proteases in the bone niche leads to inactivation of extracellular serpins, premature degradation of VCAM-1, and loss of bone marrow retention |
697537 |
| 3.2.1.18 | medicine |
isoform Neu2 mRNA and enzymatic activity are significantly increased in hypertrophic myofibers. Constitutive activation of AKT or Igf-1 treatment as well as treatment with vasopressin or trichostatin results in rise in Neu2 activity. Myofiber atrophy obtained by dexamethasone treatment or starvation triggers a significant loss of Neu2 activity and is paralleled by downregulation of Neu2 transcript levels |
695987 |
