EC Number   |
Application |
Reference |
|---|
   3.2.1.108 | food industry |
the enzyme is used for the production of dairy products |
732766 |
| 3.2.1.108 | medicine |
absorption of quercetin-3-glucoside requires hydrolysis by the enzyme, absorption of quercetin-4-glucoside requires both an interaction with sodium-dependent glucose transporter and hydrolysis by the enzyme |
654552 |
| 3.2.1.108 | medicine |
among 107 milk-drinking Somali camel-herders from Ethiopia, eight polymorphic sites are identified in the enhancer sequence in an intron of a neighboring gene MCM6 which modulates lactase transcription in vitro. -13915*G and -13907*G are each significantly associated with lactase persistence. Allele -14009*G has borderline association with lactase persistence, but loses significance after correction for multiple testing. Sequence diversity of the enhancer is significantly higher in the lactase persistent members of this and a second cohort compared with non-persistent members of the two groups |
709567 |
| 3.2.1.108 | medicine |
analysis of sequence variants of lactase persistence/lactase non-persistence LP/LNP in subjects originating from Northern Russia. The prevalence of the -13910C/C genotype among 148 patients was 28.4%. A G to A variant residing 13914 bp upstream from the LCT gene, -13914G/A, was identified in one participant carrying the -13910C/C genotype. The -13914G/A variant in heterozygous state is associated with increased lactase activity, suggesting that the increased lactase activity is most likely to be associated with the -13914G/A variant |
710555 |
| 3.2.1.108 | medicine |
C/T-13910 cis-acting regulatory variant located around 14 kb upstream of lactase gene completely correlates with lactase phenotype in Indian children. The genetic testing for the C/T -13910 variant may be helpful in the diagnosis of adult-type hypolactasia in Indian children |
714761 |
| 3.2.1.108 | medicine |
enzyme plays a major role in metabolism of glycosilated phytochemicals |
657409 |
| 3.2.1.108 | medicine |
findings facilitate genetic testing and enable genetic counseling for congential lactase deficiency, CLD |
683038 |
| 3.2.1.108 | medicine |
in irritable bowel syndrome, IBS, patients, genotyping of C/T_13910 and G/A_22018 polymorphisms predicts gastrointestinal symptoms after lactose ingestion and are a diagnostic tool for lactose intolerance |
683371 |
| 3.2.1.108 | medicine |
the C allele of the T-13910C polymorphism causing lactose intolerance is associated with lower dietary calcium intake and serum calcium levels but not with bone mineral density or fractures. The associations observed with height and vertebral area were the result of population stratification |
709206 |
| 3.2.1.108 | medicine |
the T/G-13915 variant is the founder mutation of lactase persistence, the result has implications for genetic testing of adult-type hypolactasia |
683765 |
