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Results 1 - 6 of 6
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EC Number Application Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.1.6.14medicine application of human N-acetylglucosamine 6-sulfatase, expressed in Chinese hamster ovary cells as a reversal agent for ultra-low molecular weight heparin. The enzyme removes a single 6-O-sulfo group at the non-reducing end of the ultra-low molecular weight heparin Arixtra (fondaparinux) effectively removing its ability to bind to antithrombin and preventing its inhibition of coagulation factor Xa 729709
Display the word mapDisplay the reaction diagram Show all sequences 3.1.6.14medicine defect in enzyme function leads to mucopolysaccharidosis type IIID, i.e. Sanfilippo syndrome Type D 652758
Display the word mapDisplay the reaction diagram Show all sequences 3.1.6.14medicine endocytosis of the recombinant enzyme by human fibroblasts 135594
Display the word mapDisplay the reaction diagram Show all sequences 3.1.6.14medicine heparan sulfate storage disorder not keratan storage disorder 135584, 135585
Display the word mapDisplay the reaction diagram Show all sequences 3.1.6.14medicine normal activity in patient G.G.,cell line GM 2243 135583
Display the word mapDisplay the reaction diagram Show all sequences 3.1.6.14medicine Sanfilippo D Syndrome: N-acetylglucosamine 6-sulfate sulfatase deficiency, mucopolysaccharidosis type IIID 135582, 135586
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