EC Number   |
Application |
Reference |
|---|
   3.1.4.53 | medicine |
enzyme knock-down by RNAi reveals that it may be complemented by isoform PDEB1, but simultaneous ablation of PDEB1 and PDEB2 leads to cell death in bloodstream form trypanosomes. In vivo application of RNAi completely prevents infection and eliminates ongoing infections |
679729 |
| 3.1.4.53 | medicine |
enzyme knock-down by RNAi reveals that it may be complemented by isoform PDEB2, but simultaneous ablation of PDEB1 and PDEB2 leads to cell death in bloodstream form trypanosomes. In vivo application of RNAi completely prevents infection and eliminates ongoing infections |
679729 |
| 3.1.4.53 | medicine |
enzyme variants PDE4B and/or PDE4D regulate cell growth through cAMP targets in the HMG malignant melanoma cell |
682216 |
| 3.1.4.53 | medicine |
expression of phosphodiesterases PDE1A, PDE1C, PDE3B, and PDE5A is enhanced in pulmonary arterial smooth muscle cells from both patients with idiopathic pulmonary arterial hypertension or secondary pulmonary hypertension compared with control. Increase in phosphodiesterase isoforms, particularly in PDE1C, contributes to decreased cAMP levels and increased proliferation of pulmonary arterial smooth muscle cells in patients with pulmonary hypertension |
677481 |
| 3.1.4.53 | medicine |
interactions of PDE4D5 with both the N- and C-terminal domains of beta-arrestin are essential for beta2-adrenoceptor regulation |
678059 |
| 3.1.4.53 | medicine |
isoform PDE7B is a drug target in chronic lymphocytic leukemia |
713394 |
| 3.1.4.53 | medicine |
PDE4 may be of particular importance as an antidepressant target in that it is regulated by repeated treatment with both norepinephrine and serotonin reuptake inhibitors as well as by the PDE4 inhibitor rolipram |
668118 |
| 3.1.4.53 | medicine |
PDE5 inhibition improved short-term object recognition performance after an acute tryptophan depletion induced deficit |
692197 |
| 3.1.4.53 | medicine |
PDE5 inhibition is a efficacious oral therapy for erectile dysfunction |
711812 |
| 3.1.4.53 | medicine |
phosphodiesterase 4B mediates Streptococcus pneumoniae-induced mucin gene MUC5AC up-regulation by inhibiting the expression of a negative regulator MKP-1, which in turn leads to enhanced MAPK ERK activation and subsequent up-regulation of MUC5AC. PDE4B inhibits MKP-1 expression in a cAMP-PKA-dependent manner. PDE4-specific inhibitor rolipram inhibits Streptomyces pneumoniae-induced MUC5AC up-regulation both in vitro and in vivo. PDE4B plays a critical role in MUC5AC induction. Topical and post-infection administration of rolipram into the middle ear potently inhibits Streptomyces pneumoniae-induced MUC5AC up-regulation |
729990 |
