EC Number   |
Application |
Reference |
|---|
   3.1.3.9 | medicine |
arthritic rats present reduced activities of the hepatic enzyme |
650398 |
| 3.1.3.9 | medicine |
crucial enzyme involved in glucose homeostasis |
680655 |
| 3.1.3.9 | medicine |
deficiency in enzyme causes glycogen storage disease type 1, and s large number of enzyme mutations is identified in glycogen storage disease type 1a patients |
652292 |
| 3.1.3.9 | medicine |
deficiency in enzyme causes glycogen storage disease type 1a |
652342 |
| 3.1.3.9 | medicine |
exposure of newborn rats to mercury increases the hepatic alanine aminotransferase activity by fold and glucose 6-phosphatase activity by 75%. Zinc pre-exposure prevents totally and partially these mercury alterations, respectively. In vitro, HgCl2 inhibits the serum and liver alanine aminotransferase by 22% and 54%, respectively, serum and liver lactate dehydrogenase by 53% and 64%, respectively, and liver and kidney glucose 6-phosphatase from 10- to 13-day-old rats by 53% and 41%, respectively |
729542 |
| 3.1.3.9 | medicine |
glucose-6-phosphatase-alpha expression is elevated in glioblastoma when compared to normal brain. Human-derived brain tumor initiating cells utilize the enzyme to counteract glycolytic inhibition induced by 2-deoxy-D-glucose and sustain malignant progression. Down-regulation of the enzyme renders the majority of these cells unable to survive glycolytic inhibition, and promotes glycogen accumulation through the activation of glycogen synthase and inhibition of glycogen phosphorylase. Brain tumor initiating cells that survive enzyme knockdown are less aggressive, displaying reduced migration, invasion, proliferation, and increased astrocytic differentiation |
730376 |
| 3.1.3.9 | medicine |
IGRP is a member of the glucose-6-phosphatase family of proteins and the major autoantigen for autoimmune type 1 diabetes. DR0301-restricted IGRP-specific T cells present in 100% of healthy subjects and type 1 diabetes subjects. DR0401-restricted IGRP-specific T cells present in ca. 80% of the subjects. Cross-reactivity between IGRP and G6Pase-alpha epitopes for DR0401-restricted T cells |
681192 |
| 3.1.3.9 | medicine |
increased hexokinase activity and decreased glucose-6-phosphatase activity in the liver of the woodchuck model of hepatitis virus-induced hepatocellular carcinoma |
673171 |
| 3.1.3.9 | medicine |
inhibitors of liver enzyme involved in either glycogenolysis or glyconeogenesis ara potential targets for development of new drugs as alternatives to the existing treatments of type 2 diabetes |
650557 |
| 3.1.3.9 | medicine |
inhibitory effect of silibinin on both hepatic glucose-6-phosphatase and gluconeogenesis may be of interest in treatment of type 2 diabetes |
679106 |
