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EC Number Application Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.1.25.1analysis - 170706
Display the word mapDisplay the reaction diagram Show all sequences 3.1.25.1medicine application of the enzyme packaged in an engineered liposome delivery vehicle to humans suffering the disease xeroderma pigmentosum due to DNA damage by UV radiation reverses the defective repair in these cells, it traverses the stratum corneum, reaches the nuclei of living skin cells, and enhances the repair of UV-induced cyclobutane pyrimidine dimers 656845
Display the word mapDisplay the reaction diagram Show all sequences 3.1.25.1molecular biology the enzyme is used as a gold standard for detection and/or calibration of DNA lesions (T4 endonuclease V-sensitive sites) caused by UVA damage 691338
Display the word mapDisplay the reaction diagram Show all sequences 3.1.25.1molecular biology UV-induced cell damage in xeroderma pigmentosa cells can be repaired by properly delivered T4 endonuclease V and can be used as a model for investigation of DNA repair, mutagenesis, and cell signaling without manipulation of the genome 656845
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