EC Number   |
Application |
Reference |
|---|
   3.1.22.1 | analysis |
microtiter plate assay for quantification of enzyme activity in biological fluids. Assay is based on hydrolysis of 974 bp PCR product labeled with biotinylated forward and fluorescein-labeled reverse primers |
681215 |
| 3.1.22.1 | medicine |
DNase II in macrophage lysosomes is responsible for definitive erythropoiesis in mouse fetal liver |
697574 |
| 3.1.22.1 | medicine |
DNase II in Trichinella spiralis are secreted into circulation to cleave undigested DNA from apoptotic host cells, which reduces the innate immune response. The role played by DNase II in Trichinella spiralis may be a self-protective mechanism. DNase IIbeta or DNase II of Trichinella spiralis can be considered a candidate protein for therapy of autoimmune diseases, DNase IIdeficient diseases, or cancer |
697574 |
| 3.1.22.1 | medicine |
epidermal growth factor triggers a cleavage of Leukocyte Elastase Inhibitor precursor into L-DNase II, its subsequent enzymatic activation and nuclear translocation. Epidermal growth factor-induced cell death can be blocked by paraptosis inhibitor AIP-1/alix |
677615 |
| 3.1.22.1 | medicine |
high expression of LEI in tumor cells may reduce the efficiency of etoposide as a chemotherapeutic agent. LEI inhibits cathepsin D, released from the lysosome during etoposide treatment. Cathepsin D enhances caspase activity in the cell by cleaving procaspase-8 and LEI overexpression slows down this cleavage, protecting cells from apoptosis |
696403 |
| 3.1.22.1 | medicine |
immunization of healthy rabbits with DNase II produces IgGs with intrinsic DNase and RNase activities. 10% of the total IgG DNase and RNase activities belong to anti-idiotypic antibodies to DNase II (ca. 0.1% of total pIgGs), while 90% of the activities do not interact with Sepharose bearing antibodies against DNase II and might be antibodies to nucleic acids bound to DNase II. Fraction of abzymes hydrolyzing both DNA and RNA can contain subfraction of antibodies against DNase II |
698294 |
| 3.1.22.1 | medicine |
incubation of retinal cells in the presence of corticoids induces a specific and dose-dependent reduction of cell viability. L-Dnase II is not involved |
682045 |
| 3.1.22.1 | medicine |
is involved in apoptosis, LEI/LDNase II is activated mostly after metabolic stress |
696131 |
| 3.1.22.1 | medicine |
non-synonymous single nucleotide polymorphisms in the DNase II gene may have clinical implications in relation to the prevalence of autoimmune diseases |
708175 |
| 3.1.22.1 | medicine |
polymorphisms in the DNase II gene might play important roles in controlling renal disorder among patients with systemic lupus erythematosus |
665907 |
