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EC Number Application Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.86medicine cGAS activates the AKT and ERK pathways to promote the inflammatory response of rheumatoid arthritis fibroblast-like synoviocytes 738972
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.86medicine cGAS and Ifi204 cooperate to sense cytosolic dsDNA and rancisella. novicida infection to produce a strong type I IFN response 738791
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.86medicine complete interferon IFN-beta induction by live Neisseria gonorrhoeae depends on both cGAS and toll-like receptor TLR4. Type I IFN is detrimental to the host, and dysregulation of iron homeostasis genes may explain lower bacteria survival in cGAS-/- and TLR4-/- cells 738006
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.86medicine Mycobacterium tuberculosis activates cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase cGAS in macrophages to produce cGAMP, that activates the adaptor protein stimulator of interferon genes STING to induce type I interferons and other cytokines 737999
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.86medicine the enzyme is a target for treatment of Huntigton disease 762288
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