EC Number   |
Application |
Reference |
|---|
   2.7.13.3 | medicine |
NME1 expression is associated with reduced overall and event-free survival of neuroblastoma patients and with the strongest associations of any of the NME family member genes. NME1 expression is also higher in tumors with MYCN oncogene amplification and in tumors from patients with stage 4 disease. Isoforms NME1/NMe2 and multiple phosphorylated His-containing proteins are found in all tested neuroblastoma cell lines and in xenograft neuroblastoma tumors. NME1 expression is asssociated with neuroblastoma cell migration and differentiation |
761309 |
| 2.7.13.3 | medicine |
significance in pathological virulence of Salmonella enterica, seductive target for anti-bacterial therapeutic development |
680184 |
| 2.7.13.3 | more |
15 of the 30 known Escherichia coli histidine kinases contain a single HAMP domain, has an important role in signal transduction |
680184 |
| 2.7.13.3 | more |
44 genes for Hiks on the chromosome, Hik34 might act as a negative regulator of the expression of heat-shock genes during normal growth. Hik33 is a cold sensor, participates in the positive regulation of the expression of more than 60% of the cold-inducible genes, is also involved in the perception of hyperosmotic stress and salt stress and transduction of the signals, findings cannot be explained by the current model of two-component systems |
682274 |
| 2.7.13.3 | more |
a LOV domain at the N-terminus, followed by a PAS domain in the intervening sequence, and a histidine kinase at the C-terminus |
682858 |
| 2.7.13.3 | more |
BOS1 is necessary for normal osmoregulation, is not the general oxidative stress signal transducer, is required for normal macroconidiation and full virulence |
-, 682026 |
| 2.7.13.3 | more |
great effect of temperature on the dynamics of the HAMP linker domain, which is a key feature in signal transduction |
-, 680202 |
| 2.7.13.3 | more |
Hik33, Hik34, Hik16 and Hik41, are involved in perception and transduction of H2O2 signals that regulate the gene expression of 26 of the 77 H2O2-inducible genes with induction factors higher than 4.0, Hik33 is the main contributor |
682377 |
| 2.7.13.3 | more |
hybrid histidine protein kinase in which four signalling domains are required for full activity |
681991 |
| 2.7.13.3 | more |
induces phosphorylation of its concomitant response regulator RaxR |
-, 682036 |
