EC Number   |
Application |
Reference |
|---|
   2.7.12.2 | agriculture |
quantitative trait locus Qsd2-AK at SD2 is the single major determinant explaining the difference in seed dormancy between the dormant cultivar Azumamugi (Az) and the nondormant cultivar Kanto Nakate Gold (KNG). The dormant Az allele of MKK3 is recessive, the N260T substitution in this allele decreases MKK3 kinase activity and appears to be causal for Qsd2-AK. The N260T substitution occurs in the immediate ancestor allele of the dormant allele, and the established dormant allele became prevalent in barley cultivars grown in East Asia, where the rainy season and harvest season often overlap |
760932 |
| 2.7.12.2 | analysis |
development of a continuous spectrophotometric assay for mitogen-activated protein kinase kinases |
739844 |
| 2.7.12.2 | analysis |
development of a protein chip consisting of a silicone elastomer microwell array with recombinant enzyme covalently attached to the wells via a 3-glycidoxypropyltrimethoxysilane crosslinker for large scale activity assay, overview |
662926 |
| 2.7.12.2 | drug development |
because of their importance in cell proliferation and signaling, MAPK pathways are being targeted for drugs for oncology, inflammation and other conditions. MEK inhibitors may be beneficial for cancer therapy. MEK inhibition is likely to be of particular importance in specific tumors where the MEK pathway is highly and directly activated |
740419 |
| 2.7.12.2 | drug development |
design and synthesis of a new series of MEK1 inhibitors, the 4-anilino-5-carboxamido-2-pyridones |
681316 |
| 2.7.12.2 | medicine |
acts as tumor suppressor, but can also promote tumor growth, plays a role in liver formation, the immune system and cardiac hypertrophy, contributes to optimal c-Jun N-terminal kinase activation |
682214 |
| 2.7.12.2 | medicine |
important role for MKK4 pathways in controlling cancer development, has a tumor suppression function, the MKK4 gene is mutated at a frequency of 5% in a number of cancer types. In contrast, studies in other cell types suggest that MKK4 and c-Jun N-terminal kinase participate in tumor promotion |
682214 |
| 2.7.12.2 | medicine |
key activator of p38 MAPK in glioma, MKK3 activation is strongly correlated with p38 activation in vitro and in vivo, strong promoter of tumor invasion, progression, and poor patient survival, interference with MKK3 signaling through a novel treatment combination of p38 inhibitor plus temozolomide heightens the vulnerability of glioma to chemotherapy |
681871 |
| 2.7.12.2 | medicine |
MKK inhibition by anthrax lethal toxin LeTx is a broadly effective strategy for targeting neovascularization in fibrosarcomas and other similar proliferative lesions |
688931 |
| 2.7.12.2 | medicine |
MKK4 immunolabeling detects precursor lesions of gastric adenocarcinoma that are otherwise clinically, radiographically, and endoscopically inapparent, is useful in the diagnosis and therapeutic targeting of gastric adenocarcinoma precursor lesions |
679010 |
