EC Number   |
Application |
Reference |
|---|
   2.7.11.23 | medicine |
IE2 and multiple cellular factors needed for viral RNA synthesis accumulate within the first 8 h at the viral transcriptosome, functional cdk activity is required for the specific recruitment of cdk7 and cdk9 during this time interval |
681696 |
| 2.7.11.23 | medicine |
the bromodomain protein, BRD4, is a therapeutic target in acute myeloid leukemia, multiple myeloma, Burkitts lymphoma, NUT midline carcinoma, colon cancer, and inflammatory disease. Loss of the enzyme BRD4 is a prognostic signature for metastatic breast cancer |
741328 |
| 2.7.11.23 | more |
Ctk1 controls the maintenance of suppressive chromatin in the coding regions of genes by both promoting H3K36 methylation, which leads to histone deacetylation, and preventing the 3' spread of H3K4 trimethylation, a mark associated with transcriptional initiation |
-, 681926 |
| 2.7.11.23 | more |
functions in translation by enhancing decoding fidelity, Ctk1 interacts with the transcription and mRNA export complex, which couples transcription to mRNA export, may bind to correctly processed mRNPs during transcription and accompany the mRNP to the ribosomes in the cytoplasm, where Ctk1 enhances efficient and accurate translation of the mRNA, function of Ctk1 in translation seems to be conserved in evolution |
680010 |
| 2.7.11.23 | more |
required for accurate transcription initiation and transcription elongation |
680554 |
