EC Number   |
Application |
Reference |
|---|
   2.4.2.31 | agriculture |
engineering strategy for the creation of a plant-tolerated, zymogen-like form of an otherwise toxic protein. Engineering of a random propeptide library at the C-terminal end of ADP-ribosyltranferase Vip2 and selecting for malfunctional enzyme variants in yeast leads to a proenzyme proVip2 which possesses reduced enzymatic activity as compared with the wild-type Vip2 protein, but remains a potent toxin toward rootworm larvae. The zymogenized Vip2 can be proteolytically activated by rootworm digestive enzyme machinery |
728720 |
| 2.4.2.31 | agriculture |
the enzyme is used as insectizide |
739000 |
| 2.4.2.31 | medicine |
isolation of ADP-ribosyltransferase toxin CDT producing strains of Peptoclostridium difficile from Equidae with gastro-intestinal disease. Out of 17 strains isolated from Equidae, 11 are positive for the genes tcdA and tcdB encoding ToxA and ToxB. In addition four of these 11 isolates are positive for the cdtA gene encoding the catalytic subunit of the ADP-ribosyltransferase CDT |
727538 |
| 2.4.2.31 | medicine |
Peptoclostridium difficile can be divided into at least five diffent toxin-producing groups: large clostridial cytotoxins producers, large clostridial cytotoxins and binary toxin producers, toxin B-only producers, toxin B and binary toxin producers and binary toxin-only producers. These groupings add further support to the theory Peptoclostridium difficile is divided into stable subpopulations that have evolved from common ancestors |
727540 |
