EC Number   |
Application |
Reference |
|---|
   2.4.1.80 | drug development |
the enzyme is an attractive target for drug development both in relation to lysosomal storage disorders (in particular Gaucher disease) and type2 diabetes |
735962 |
| 2.4.1.80 | medicine |
- |
489419, 489421 |
| 2.4.1.80 | medicine |
enzyme inhibition is a possible target for chemotherapeutic agents for a number of diseases, including cancer |
489419, 489421 |
| 2.4.1.80 | medicine |
GCS expression is significantly down-regulated in Alzheimer brain |
691551 |
| 2.4.1.80 | medicine |
it is shown that pharmacological lowering of glycosphingolipids, without significant reduction of ceramide, dramatically reverses insulin resistance in in vitro and in vivo models and may present a novel approach to the therapy of type 2 diabetes |
679436 |
| 2.4.1.80 | medicine |
potential therapeutic target for inherited sphingolipidoses such as Gaucher, Fabry, and Tay-Sachs disease |
489420 |
| 2.4.1.80 | medicine |
results show that high level of GCS in leukemia cells is associated with multidrug resistance of these cells |
693944 |
| 2.4.1.80 | medicine |
substrate inhibition therapy with Genz-112638 represents a viable alternate approach to enzyme therapy to treat the visceral pathology in Gaucher disease |
681954 |
| 2.4.1.80 | molecular biology |
glucosylceramide is essential for MsDef1-mediated growth inhibition of Fusarium graminearum, but not for its pathogenicity |
694220 |
| 2.4.1.80 | pharmacology |
enzyme might be an attractive target for malarial chemotherapy |
658636 |
