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2.4.1.345
analysis
development of a cell-free assay. Membranes from Mycobacterium smegmatis overexpressing the pimA gene incorporate mannose from GDP-[14C]Man into di- and tri-acylated phosphatidylinositol mono-mannosides
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659183
2.4.1.345
medicine
PimA is required for viability during macrophage infection. In two different mouse models of infection a dramatic decrease in viable counts is observed upon silencing of the gene. Depletion of PimA results in complete clearance of the mouse lungs during both the acute and chronic phases of infection
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736363
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