EC Number   |
Application |
Reference |
|---|
   2.4.1.144 | diagnostics |
GnT-III expression levels are elevated in high-grade serous ovarian carcinoma tissues and correlate with reduced survival |
759483 |
| 2.4.1.144 | medicine |
apart from GnT-III overexpression, engineering of GnT-III localization is a versatile tool to modulate the biological activities of antibodies relevant for their therapeutic application |
672706 |
| 2.4.1.144 | medicine |
enzyme activity in extrahepatic bile duct carcinoma is increased 3fold compared to mean enzyme activity values, resulting in increased bisecting-GlcNAc on the glycans of glycoproteins in cancer tissues and a 201 kDa bile glycoprotein |
658862 |
| 2.4.1.144 | medicine |
enzyme activity is elevated in serum of 60 out of 86 patients with liver cirrhosis, and of 86 out of 91 patients with chronic hepatitis |
658860 |
| 2.4.1.144 | medicine |
enzyme activity is elevated in three choriocarcinoma cell lines compared to normal placenta. Activity in JEG-3 cells is 27 times higher than normal |
658863 |
| 2.4.1.144 | medicine |
the majority of N-glycans of a recombinant antibody produced in Nicotiana tabacum expressing GnT-III is bisected and devoid of paucimannosidic structures. This might improve the efficacy of therapeutic antibodies produced in the transgenic plants |
673888 |
| 2.4.1.144 | medicine |
therapeutic potential of inhibiting GnT-III as a treatment for controlling epithelial ovarian carcinoma (EOC) growth and recurrence |
759483 |
| 2.4.1.144 | synthesis |
introduction of human N-acetylglucosaminyltransferase gene into tobacco plants leads to highly efficient synthesis of bisected N-glycans. The majority of N-glycans of an antibody produced in a plant expressing GnT-III is also bisected. This might improve the efficacy of therapeutic antibodies produced in this type of transgenic plant |
673888 |
| 2.4.1.144 | synthesis |
overexpression of enzyme in human hepatoma cells fails to reduce branch formation of N-glycans, coexpression of caveolin-1 leads to a dramatic decrease in the extent of branching with no enhancement of enzyme activity |
659223 |
| 2.4.1.144 | synthesis |
RC12 cells, apheochromocytoma cell line, transfected with enzyme gene, result in suppression of neurite outgrowth induced by costimulation of epidermal growth factor and integrins. Epidermal growth factor receptor-mediated ERK-activation is blocked in transfectants. Epidermal growth factor receptor of transfectants is modified by bisecting GlcNAc in its N-glycan structures |
658847 |
