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Results 1 - 9 of 9
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EC Number Application Commentary Reference
Show all pathways known for 2.3.1.157Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.157drug development due to developed resistance against the existing anti-tubercular drugs by Mycobacteriumm tuberculosis, the enzyme is a target for drug development. Targeting uridyltranferase activity of Mtu GlmU would be a better choice for therapeutic intervention, since at low metabolite concentrations, inhibition of either of the GlmU reactions cause significant decrement in the overall GlmU rate, but at higher metabolite concentrations, uridyltransferase inhibition shows higher decrement, overview 720872
Show all pathways known for 2.3.1.157Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.157drug development GlmU is a target for drug development against Mycobacteria 718708
Show all pathways known for 2.3.1.157Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.157drug development GlmU is a target for inhibitor design -, 719986
Show all pathways known for 2.3.1.157Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.157drug development the enzyme GlmU is a target for development of antibacterial drugs 720042
Show all pathways known for 2.3.1.157Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.157drug development the enzyme is a target for inhibitor development in treatment of tuberculosis 720042
Show all pathways known for 2.3.1.157Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.157medicine arylsulphatase AtsG , bifunctional glucosamine-1-phosphate acetyltransferase and N-acetylglucosamine-1-phosphate uridyl transferase GlmU and S-adenosyl-L-homocysteine hydrolase SahH are the Mycobacterium tuberculosis proteins that bind to human IL-8. The interactions with IL-8 are characterized by high binding affinity with KD values of 6.83x10-6 M, 5.24x10-6 M and 7.14x10-10 M, respectively. Strains overproducing the enzymes show a significantly increased number of intracellularly located bacilli compared with those of wild-type -, 737096
Show all pathways known for 2.3.1.157Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.157medicine GlmU is a potential antituberculosis drug target, a microtiter plate assay for GlmU activity as read out is developed -, 687124
Show all pathways known for 2.3.1.157Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.157medicine GlmUMtb is a strong candidate for intervention measures against established tuberculosis infections -, 737150
Show all pathways known for 2.3.1.157Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.157more the increase in activity induced by some substitutions and truncations may be a useful feature that can be exploited for commercial application of this enzyme -, 729696
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