EC Number |
Application |
Reference |
---|
2.1.2.2 | diagnostics |
GART expression is associated with glioma grade and high GART protein expression might be related to poor outcome |
736945 |
2.1.2.2 | diagnostics |
increased expression of glycinamide ribonucleotide transformylase is associated with a poor prognosis in hepatocellular carcinoma |
736225 |
2.1.2.2 | medicine |
- |
485731, 485735, 485737 |
2.1.2.2 | medicine |
glycinamide ribonucleotide transformylase has emerged as a productive target for antineoplastic therapeutic intervention |
688291 |
2.1.2.2 | medicine |
glycinamide ribonucleotide transformylase is a validated target for cancer chemotherapy |
685128 |
2.1.2.2 | medicine |
high GART expression is observed in glioma and is related to the grade of malignancy. GART overexpression is significantly associated with overall survival. Transfecting cells with GART-siRNA suppresses proliferation and enhances temozolomide-induced apoptosis in glioma cells |
745966 |
2.1.2.2 | medicine |
inhibitor 5,10-dideazatetrahydrofolate is antiproliferate and cytotoxic against mammalian tumor cells in culture and have broad spectrum activity against transplantable mouse tumors and human tumor xenografts |
485731, 485737 |
2.1.2.2 | medicine |
pharmacological importance, target enzyme for chemotherapy, development of novel antifolate drugs, to be used as anti-cancer drugs |
485715, 485719, 485724, 485725, 485734, 485738, 485740, 485741 |
2.1.2.2 | medicine |
target for structure-based drug design |
485719 |