Any feedback?
Please rate this page
(search_result.php)
(0/150)

BRENDA support

Refine search

Search Application

show results
Don't show organism specific information (fast!)
Search organism in taxonomic tree (slow, choose "exact" as search mode, e.g. "mammalia" for rat,human,monkey,...)
(Not possible to combine with the first option)
Refine your search

Search term:

Results 1 - 10 of 47 > >>
download as CSV
download all results as CSV
EC Number Application Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.67analysis determination of thiopurine S-methyltransferase activity in erythrocytes using 6-thioguanine as substrate and a non-extraction liquid chromatographic technique. This method minimzes sample-handling, reduces inherent imprecision, the possibility of laboratory error and with the potential for further automation, makes it ideal for use in a regional refferal laboratory 659566
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.67analysis monitoring of 6-thiopurine S-methyltransferase activity is especially important when patients are treated with 6-thiopurine drugs (drugs in treatment of acute lymphoblastic leukemia), since severe bone marrow toxicity may be induced if patients have deficient 6-thiopurine S-methyltransferase activity. The HPLC-based method enables the rapid screening of 6-6-thiopurine S-methyltransferase activities in patients treated with 6-thiopurines 657544
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.67analysis monitoring of TPMT activity may be of benefit to improve thiopurine therapy 658653
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.67diagnostics the chip-based miniaturization provides a clinically feasible genotyping platform for one-at-a-time testing 688452
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.67diagnostics thiopurine S-methyltransferase genotypes or phenotypes may be a predictive factor for azathioprine-induced toxicities 688777
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.67medicine - 485522, 485523, 485524, 485525, 485526
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.67medicine azathioprine sodium is a purine antagonist commonly used as an adjuvant immunosuppressive agent in treating Pemphigus Vulgaris, mercaptopurine is the active compound, TPMT is the principal inactivation enzyme for this cytotoxic metabolite in hematopoietic tissues 684733
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.67medicine detecting TPMT genetic variants before the administration of azathioprine has the potential to prevent serious and costly adverse drug reactions, such as neutropenia 687195
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.67medicine determination of TPMT and monitoring of thiopurine metabolites allows azathioprine treatment to be optimised 701657
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.67medicine enzyme activity might represent one factor responsible for variations in the therapeutic or toxic effects of thiopurine and thiopyrimidine drugs used clinically to treat recipients of transplanted kidneys and patients with renal disease such as glomerulonephritis 485518
Results 1 - 10 of 47 > >>
download as CSV
download all results as CSV