EC Number   |
Application |
Reference |
|---|
   2.1.1.63 | analysis |
ability to specifically label AGT fusion proteins in the presence of endogenous AGT, after brief incubation of the cells with a small-molecule inhibitor, may significantly broaden the scope of application of AGT fusion proteins for studying protein function in living cells |
673072 |
| 2.1.1.63 | analysis |
N-terminal domain plays a critical structural role in maintaining an active configuration of the C-terminal domain, N-hAGT and C-hAGT domains can protect from N-methyl-N'-nitro-N-nitrosoguanidine in Escherichia coli GWR-109 cells |
671999 |
| 2.1.1.63 | analysis |
overexpression of human MGMT provides protection against the toxic effects of N-methyl-N'-nitro-N-nitrosoguanidine |
676201 |
| 2.1.1.63 | analysis |
strategy of loop insertion to alter enzyme specificity shall be general and applicable to other classes of proteins, the isolated AGT mutant can be applied in molecular imaging, where the mutant and parental AGTs are used to label two different AGT fusion proteins with different fluorophores in the same living cell or in vitro, allows establishment of fluorescence-based assays to detect protein-protein interactions and measure enzymatic activities |
671026 |
| 2.1.1.63 | diagnostics |
introduction of the MS-MLPA assay may not only be helpful for predicting response of gliomas to temozolomide, but may also facilitate tailor-made treatment with other chemotherapeutic agents for a variety of tumors |
688740 |
| 2.1.1.63 | drug development |
highly effective inactivation of MGMT by an oligodeoxyribonucleotide containing O6-(4-bromothenyl)guanine suggests that such oligodeoxyribonucleotides might have therapeutic applications if problems of delivery can be addressed |
676204 |
| 2.1.1.63 | medicine |
a deficient enzyme status in pancreatic neuroendocrine tumors is not associated with a better response to temozolomide-based chemotherapy and cannot be used as a predictive marker to lead treatment decisions |
756640 |
| 2.1.1.63 | medicine |
a larger number of methylated CpG sites in the enzyme promoter region is associated with a favorable outcome of medulloblastoma |
757666 |
| 2.1.1.63 | medicine |
AGT-DNA cross-linking is a likely mechanism of 1,2,3,4-diepoxybutane-mediated cytotoxicity in cells expressing this important repair protein |
673065 |
| 2.1.1.63 | medicine |
alkyltransferase activity in tumors protects them from therapeutic agents such as temozolomide and N,N'-bis(2-chloroethyl)-N-nitrosourea, polymorphisms in the AGT gene |
673219 |
