EC Number |
Application |
Reference |
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2.1.1.319 | medicine |
modulating PRMT1 activity may represent new avenues to regulate thermogenic fat and mediate energy homeostasis and may ultimately lead to therapeutic strategies against human obesity and associated metabolic disorders |
756600 |
2.1.1.319 | medicine |
oxidative stress induces apoptosis both via isoform PRMT1 in a SIRT1-dependent manner and via PRMT4 in a SIRT1-independent manner |
734831 |
2.1.1.319 | medicine |
potential application of PRMT1 inhibitors in cancer treatment |
756181 |
2.1.1.319 | medicine |
PRMT1 and PRMT5 have opposing effects on chemotherapeutic agent-mediated apoptosis in lung cancer cells. The identification of PRMT5 and PRMT1 as CFLARL regulators involved in cellular apoptosis may help in developing new strategies to increase the sensitivity of cancer cells to chemotherapy, which may eventually benefit lung cancer treatments |
757337 |
2.1.1.319 | medicine |
splive variant PRMT1 v.2 promotes the survival and invasiveness of breast cancer cells, while it could serve as a biomarker of unfavorable prognosis in colon cancer patients |
756861 |