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EC Number Application Commentary Reference
Show all pathways known for 2.1.1.20Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.20diagnostics enzyme level suitable as prognostic marker for human cholangiocarcinoma and hepatocellular carcinoma 688121
Show all pathways known for 2.1.1.20Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.20diagnostics partially suitable to distinguish between benign and malign tumor forms 673122
Show all pathways known for 2.1.1.20Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.20medicine activation and induction of enzyme by retinoids are tissue- and gender-specific 485232
Show all pathways known for 2.1.1.20Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.20medicine all-trans-retinoic acid and dexamethasone independently induce GNMT in liver, thereby having substantial implications for the potential interaction of retinoic administration with diabetes 659768
Show all pathways known for 2.1.1.20Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.20medicine diabetes increases the activity and abundance of GNMT, lack of dietary folate results in the highest activity of GNMT in diabetic rats without the abundance of the protein being altered 671233
Show all pathways known for 2.1.1.20Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.20medicine feeding with excess methionine leads to upregulation of hepatic enzyme 485229
Show all pathways known for 2.1.1.20Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.20medicine glycine N-methyltransferase is a tumor susceptibility gene for both hepatocellular carcinoma and prostate cancer 703849
Show all pathways known for 2.1.1.20Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.20medicine GNMT 1289 C->T polymorphism influences plasma homocysteine and is responsive to folate intake, plasma homocysteine concentrations do not differ among the GNMT C1289T genotypes at baseline. After folate restriction, women with the GNMT 1289 TT genotype have higher homocysteine concentrations than women with the CT or CC genotype. The influence of the GNMT 1289 C->T variant on homocysteine is dependent on the MTHFR C677T genotype. In subjects with the MTHFR 677 CC genotype, homocysteine is greater for GNMT 1289 TT subjects relative to 1289 CT or CC subjects. In subjects with the MTHFR 677 TT genotype, plasma homocysteine concentrations do not differ among the GNMT C1289T genotypes 675559
Show all pathways known for 2.1.1.20Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.20medicine GNMT is a tumor suppressor gene for liver cancer, and is associated with gender disparity in liver cancer susceptibility 704068
Show all pathways known for 2.1.1.20Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.20medicine GNMT is a tumor susceptibility gene for prostate cancer, three major GNMT haplotypes in our populations, haplotype C conferred protection from the development of prostate cancer and exhibits the highest promoter activity 673122
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