EC Number   |
Application |
Reference |
|---|
   1.8.3.7 | biotechnology |
bioconjugation chemistry, formylglycine-generating enzymes catalyze the site-specific oxidation of a cysteine residue to the aldehyde-containing amino acid Ca-formylglycine (FGly). This noncanonical residue can be generated within any desired target protein and can subsequently be used for bioorthogonal conjugation reactions |
763887 |
| 1.8.3.7 | biotechnology |
site-specific bioconjugation. Formylglycine-generating enzymes allow to posttranslationally introduce the amino acid Calpha-formylglycine (FGly) into recombinant proteins, starting from cysteine or serine residues within distinct consensus motifs |
764250 |
| 1.8.3.7 | biotechnology |
site-specific conjugation strategy for dual antibody-drug conjugates using aerobic formylglycine-generating enzymes |
764242 |
| 1.8.3.7 | biotechnology |
the enzyme is an enabling biotechnology tool due to the robust utility of the aldehyde product as a bioconjugation handle in recombinant proteins |
-, 765680 |
| 1.8.3.7 | medicine |
coexpression of formylglycine-generating enzyme is essential for gene therapy of metachromatic leukodystrophy |
742628 |
