EC Number   |
Application |
Reference |
|---|
    1.2.1.24 | medicine |
GABA oxidation and SSADH activity might be additional therapeutic targets in gliomas/glioblastomas |
763330 |
| 1.2.1.24 | medicine |
SSADH (Aldh5a1) deficiency is a rare autosomal recessive disease. Hippocampal and cortical dysfunction in Aldh5a1-/- brain, but no evidence that accumulating key metabolites of SSADH deficiency directly induce impairment of energy metabolism |
694354 |
| 1.2.1.24 | medicine |
succinic semialdehyde dehydrogenase deficient patients show widespread reduction in benzodiazepine receptor binding on [(11)C]-flumazenil-positron emission tomography |
700444 |
| 1.2.1.24 | more |
genomic copy of the SSADH gene contains two introns. Multiple SSADH gene copies are present in the genome |
692620 |
| 1.2.1.24 | more |
genomic copy of the SSADH gene is devoid of introns. Multiple SSADH gene copies are present in the genome |
692620 |
| 1.2.1.24 | more |
in the world population, the c.538C variant of SSADH is proceeding to replace the ancestral c.538T, shared with primates. A significant correlation between the frequencies of the derived alleles in SSADH and microcephalin, which show concerted changes worldwide and, at least in Asian populations, also on a restricted geographical scale |
690435 |
| 1.2.1.24 | more |
yneI, responsible for NAD+/NADP+-dependent SSADH activity, plays a unique physiological role in the general nitrogen metabolism of Escherichia coli. The yneI gene has an important, but not essential, role during growth on arginine and probably has an essential function during growth on putrescine as the nitrogen source. The yneI-encoded activity functions primarily as a valve to prevent toxic accumulation of succinate semialdehyde |
-, 692836 |
