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EC Number Application Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 1.14.99.29drug development eIF5A and the hypusine biosynthetic enzymes are potential targets for intervention in aberrant cell proliferation 701650
Display the word mapDisplay the reaction diagram Show all sequences 1.14.99.29drug development the parasite enzyme is a potential target for antimalaria drug design 713727
Display the word mapDisplay the reaction diagram Show all sequences 1.14.99.29medicine ciclopirox inhibits cell proliferation and angiogenesis in vitro 438282
Display the word mapDisplay the reaction diagram Show all sequences 1.14.99.29medicine inhibition of DOHH leads to a decrease of hypusine-containing eIF5A and inhibition of eukaryotic cell growth, consequently, these results suggest that eIF5A and DOHH could be promising targets for antitumor and anti-HIV-1 therapies 700997
Display the word mapDisplay the reaction diagram Show all sequences 1.14.99.29medicine the results support the concept that drugs targeting DOHH should be tested clinically for HIV-1 inhibition and could be developed as antiretrovirals 701189
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