EC Number |
Application |
Reference |
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1.14.15.15 | medicine |
7-dehydrocholesterol is catabolized by isoform CYP27A1 to metabolites that act as selective liver X receptor LXR modulators. Metabolites detected in serum of a patient with Smith-Lemli-Opitz syndrome are 25-hydroxy-7-dehydrocholesterol which activates liver X receptors LXRalpha, LXRbeta and vitamin D receptor and 26/27-hydroxy-7-dehydrocholesterol which induces activation of LXRalpha and LXRbeta, although the activities of both compounds on LXRs are weak |
725831 |
1.14.15.15 | medicine |
the endogenous steroidal Na/K-ATPase inhibitor, marinobufagenin, is synthesized in mammalian placenta and adrenal cortex from cholesterol through the novel acidic bile acid pathway, role of marinobufagenin in highly prevalent human cardiovascular diseases |
735969 |
1.14.15.15 | medicine |
treatment of enzyme with iso[4]levuglandin E2 in vitro diminishes enzyme activity. Lys residues Lys134, Lys358, and Lys476, readily interact iso[4]levuglandin E2 in vitro, and modified CYP27A1 is present in the retina. The post-translational modifications may exemplify a general mechanism whereby oxidative stress and inflammation deleteriously affect protein function, contributing, for example, to cholesterol-rich lesions associated with age-related macular degeneration and cardiovascular disease |
725428 |