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Results 1 - 3 of 3
EC Number Application Commentary Reference
Show all pathways known for 1.14.15.15Display the word mapDisplay the reaction diagram Show all sequences 1.14.15.15medicine 7-dehydrocholesterol is catabolized by isoform CYP27A1 to metabolites that act as selective liver X receptor LXR modulators. Metabolites detected in serum of a patient with Smith-Lemli-Opitz syndrome are 25-hydroxy-7-dehydrocholesterol which activates liver X receptors LXRalpha, LXRbeta and vitamin D receptor and 26/27-hydroxy-7-dehydrocholesterol which induces activation of LXRalpha and LXRbeta, although the activities of both compounds on LXRs are weak 725831
Show all pathways known for 1.14.15.15Display the word mapDisplay the reaction diagram Show all sequences 1.14.15.15medicine the endogenous steroidal Na/K-ATPase inhibitor, marinobufagenin, is synthesized in mammalian placenta and adrenal cortex from cholesterol through the novel acidic bile acid pathway, role of marinobufagenin in highly prevalent human cardiovascular diseases 735969
Show all pathways known for 1.14.15.15Display the word mapDisplay the reaction diagram Show all sequences 1.14.15.15medicine treatment of enzyme with iso[4]levuglandin E2 in vitro diminishes enzyme activity. Lys residues Lys134, Lys358, and Lys476, readily interact iso[4]levuglandin E2 in vitro, and modified CYP27A1 is present in the retina. The post-translational modifications may exemplify a general mechanism whereby oxidative stress and inflammation deleteriously affect protein function, contributing, for example, to cholesterol-rich lesions associated with age-related macular degeneration and cardiovascular disease 725428
Results 1 - 3 of 3